Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen.
Identifieur interne : 003543 ( Main/Exploration ); précédent : 003542; suivant : 003544Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen.
Auteurs : A A Epenetos ; N. Courtenay-Luck ; D. Pickering ; G. Hooker ; H. Durbin ; J P Lavender ; C G MckenzieSource :
- British Medical Journal (Clinical research ed.) [ 0267-0623 ] ; 1985-05-18.
English descriptors
- Teeft :
- Antibody, Antibody scan, Antimalarial drug, Arterial infusion, Birth defects, Blood group, Brain gliomas, Cerebral oedema, Chloroquine, Cigarette smokers, Cigarette smoking, Control group, Conventional forms, Disease control, Dosimetry calculations, Epidermal, Epidermal growth factor receptor, Epidermal growth factor receptors, Glioma, Human services, Infusion, Journal volume, Malignant lesions, Medical services, Monoclonal, Monoclonal antibodies, Monoclonal antibody, Neoplastic tissues, Nuclear medicine, Postoperative radiotherapy, Probe counter, Radiolabelled antibody, Radiotherapy, Receptor, Recurrent grade, Smoker, States department, Tomography, Tumour, Tumour area, Tumour size, Whole body, Wide range.
Abstract
In a patient with recurrent grade IV glioma of the brain resistant to conventional treatment an antibody guided isotopic scan showed uptake by the tumour of a monoclonal antibody (9A) that was developed against epidermal growth factor receptor but cross reacted with blood group A antigen. As a therapeutic attempt antibody labelled with 1665 MBq (45.0 mCi) iodine-131 was delivered to the tumour area by infusion into the internal carotid artery. Computed tomography showed regression of the tumour after treatment, and an appreciable and sustained clinical improvement was noted without any toxicity. Delivery of irradiation guided by monoclonal antibody delivered by arterial infusion of the tumour area may be of clinical value in the treatment of brain gliomas resistant to conventional forms of treatment.
Url:
DOI: 10.1136/bmj.290.6480.1463
Affiliations:
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As a therapeutic attempt antibody labelled with 1665 MBq (45.0 mCi) iodine-131 was delivered to the tumour area by infusion into the internal carotid artery. Computed tomography showed regression of the tumour after treatment, and an appreciable and sustained clinical improvement was noted without any toxicity. Delivery of irradiation guided by monoclonal antibody delivered by arterial infusion of the tumour area may be of clinical value in the treatment of brain gliomas resistant to conventional forms of treatment.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Courtenay Luck, N" sort="Courtenay Luck, N" uniqKey="Courtenay Luck N" first="N" last="Courtenay-Luck">N. Courtenay-Luck</name><name sortKey="Durbin, H" sort="Durbin, H" uniqKey="Durbin H" first="H" last="Durbin">H. Durbin</name><name sortKey="Epenetos, A A" sort="Epenetos, A A" uniqKey="Epenetos A" first="A A" last="Epenetos">A A Epenetos</name><name sortKey="Hooker, G" sort="Hooker, G" uniqKey="Hooker G" first="G" last="Hooker">G. Hooker</name><name sortKey="Lavender, J P" sort="Lavender, J P" uniqKey="Lavender J" first="J P" last="Lavender">J P Lavender</name><name sortKey="Mckenzie, C G" sort="Mckenzie, C G" uniqKey="Mckenzie C" first="C G" last="Mckenzie">C G Mckenzie</name><name sortKey="Pickering, D" sort="Pickering, D" uniqKey="Pickering D" first="D" last="Pickering">D. Pickering</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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